Internal Exposure Simulation Based on Exposure Related Dose Estimating Model
نویسندگان
چکیده
منابع مشابه
A physiologically based pharmacokinetic/pharmacodynamic model for carbofuran in Sprague-Dawley rats using the exposure-related dose estimating model.
Carbofuran (2,3-dihydro-2,2-dimethyl-7-benzofuranyl-N-methylcarbamate), a broad spectrum N-methyl carbamate insecticide, and its metabolite, 3-hydroxycarbofuran, exert their toxicity by reversibly inhibiting acetylcholinesterase (AChE). To characterize AChE inhibition from carbofuran exposure, a physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) model was developed in the Exposure-...
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ژورنال
عنوان ژورنال: Journal of Risk Analysis and Crisis Response
سال: 2013
ISSN: 2210-8505
DOI: 10.2991/jrarc.2013.3.4.3